Roche gene testing key to US$1.7b deal for Blueprint cancer drug
[ZURICH] Roche has struck a US$1.7 billion cancer drug pact with Blueprint Medicines, it said on Tuesday, as advances in genetic testing for rare mutations drive lucrative deals for expensive treatments.
The Swiss drugmaker will pay US$675 million in cash and make a US$100 million equity investment in Blueprint for rights to pralsetinib, which could gain US approval against so-called RET-altered non-small cell lung cancer in November.
US company Blueprint, which has been working with Roche since 2016, could also receive up to US$927 million in milestone payments, plus royalties on sales outside the United States, Roche said in a statement.
Mutations to the RET gene can drive tumour growth, but given that such genetic changes occur in only a fraction of patients with lung or thyroid cancer, genetic testing is key to prescribing the most beneficial drugs.
Roche's diagnostics division is key to a deal that will enable the company to expand on a portfolio of medicines such as Alecensa and Rozlytrek, which require testing to determine which patients will benefit.
"We will leverage our global reach and expertise in oncology, as well as our capabilities in diagnostics," said James Sabry, Roche's head of partnerships.
GET BT IN YOUR INBOX DAILY
Start and end each day with the latest news stories and analyses delivered straight to your inbox.
Beyond lung cancer, Blueprint has also submitted pralsetinib to the US Food and Drug Administration (FDA) for treating advanced RET mutant and RET fusion-positive thyroid cancers.
Roche and Blueprint are not alone in combining sophisticated diagnostics with niche drugs.
Eli Lilly and Co and German drugmaker Bayer's Vitrakvi also targets tumours with a rare mutations identified by testing. Novartis and Incyte, meanwhile, won approval this year for lung cancer drug Tabrecta, which also requires genetic testing.
Both Tabrecta and Vitrakvi rely on a diagnostic test from Roche's Foundation Medicine diagnostics unit.
Though such gene mutations affect relatively few patients, the companies aim to turn their medicines into blockbusters by commanding prices running into the tens of thousands of dollars per month.
Tabrecta costs US$18,000 a month, Roche's Rozlytrek is priced similarly and Vitrakvi lists at US$32,800 a month.
REUTERS
KEYWORDS IN THIS ARTICLE
BT is now on Telegram!
For daily updates on weekdays and specially selected content for the weekend. Subscribe to t.me/BizTimes
Consumer & Healthcare
Hermes Q1 sales jump 17% on strong China demand
Cordlife’s independent auditor to retire after issuing disclaimer of opinion on FY2023 financials
Cutting the cord?: Events leading up to Cordlife’s MOH suspension and arrests of its directors, ex-group CEO
Cordlife customers push for legal action
France's Casino supermarket chain to axe up to 3,200 jobs
Prada outshines rivals with 16% revenue lift boosted by Miu Miu